Characterization of Age-related Microstructural Changes in Locus Coeruleus and Substantia Nigra Pars Compacta. (arXiv:1911.11336v1 [physics.med-ph])
Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here, we use high-resolution diffusion-weighted MRI to investigate microstructural and compositional changes in LC and SNpc in young and aged cohorts,…